They need to do a made-for-TV adaptation of the musical...
Maybe for IFC or Showtime (and I'm pretty sure that w/ Showtime, that also gives us VH1, MTV and Logo).
As for the cast:
* Christian Campbell (Ibid, Reefer Madness, Trick, Banshee) as Melvin/Toxie
* Kaley Cuoco (The Big Bang Theory, Killer Movie) as Sarah
* Susan Sarandon as The Mayor
* Harvey Fierstein as Melvin's Mom
more casting choices TBD