First Cumulative Patch Tuesday
Today is the first Cumulative Patch Tuesday. Woody Leonhard posted several worthwhile blog entries dated 10/11/2016 on his site.
To summarize his posts, don't be in a hurry to install anything. That said, from what I've read today's Oct 2016 “Security Monthly Quality Rollup” should include October security updates and the September non-security updates. So it should be relatively safe, but Woody says:
But wait for the cannon fodder to install it, for Microsoft to answer (or dodge) reports of bugs, and watch here for a switch to MS-DEFCON 3 or lower.
https://www.askwoody.com/
Considering this is a brand new process, I think it's advisable to wait a bit before installing.